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Updated: Jun 25, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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前额叶皮层中Scn1a的哈普洛缺陷导致认知障碍和抑郁的表型

Maurizio S Riga1, Mercedes Pérez-Fernández1, Lluis Miquel-Rio2,3

  • 1Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), CSIC-JA-US-UPO, Seville 41092, Spain.

Brain : a journal of neurology
|May 20, 2024
PubMed
概括

青少年前额叶皮层 (PFC) Nav1.1 功能障碍通过破坏大脑刺激和抑制导致和抑郁症. 这项研究将Nav1.1缺陷与人类的严重抑郁症 (MDD) 联系起来.

关键词:
有GABA的内部神经元.在 Nav1.1 频道上.激发性/抑制性平衡 (E/I平衡) 是一种市长 抑郁症 抑郁症前额叶皮层前额叶皮层

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