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Au/Doc/Quer@PDA/A10-3.2 纳米颗粒用于针对性治疗耐多塞的前列腺癌

Junjie Ye¹, Qi Wu¹, Qingfen Ji¹

¹Urology Department, Lishui City People's Hospital; Postgraduate training base Alliance of Wenzhou Medical University (Lishui City People's Hospital), Lishui City, Zhejiang Province, China.

Journal of biomaterials science. Polymer edition

|May 20, 2024

概括

研究人员开发了一种新的纳米粒子药物,将多塞塔克塞尔和奎尔结合起来,以克服前列腺癌的抗药性. 这种向疗法在抗性前列腺癌模型中有望提高治疗疗效.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

多塞塔克塞尔是前列腺癌 (PC) 的首要化疗方法,但因耐药性和特异性而面临挑战.
开发新型疗法对于克服多塞素耐药性和加强PC进展的向至关重要.

研究的目的:

为了合成和验证一种新的纳米复合物药物,Au/Doc/Quer@PDA/A10-3.2纳米颗粒 (NP),用于对抗抗 docetaxel 的前列腺癌.
提高药物向特异性,克服PC治疗中获得的耐药性.

主要方法:

准备 Au/Doc/Quer@PDA/A10-3.2 NPs 封装dcetaxel 和 quercetin 在聚多巴胺涂层的金纳米颗粒中,用A10-3.2 适合PSMA阳性细胞向的aptamer进行修改.
使用UV-vis,TEM,DLS,XPS和FTIR进行表征.
在体外评估向能力,细胞增殖,细胞亡,入侵,迁移和化疗敏感化机制.
在PC的小鼠模型中的体内治疗疗效评估.

主要成果:

通过各种物理方法证实了Au/Doc/Quer@PDA/A10-3.2NP的成功合成和表征.
通过光成像和流细胞测量,证明了对PSMA阳性PC细胞 (LNCaP/R) 的特定向.
奎尔素有效地逆转了LNCaP/R细胞中的多塞素耐药性,增强了抗癌作用.
这种新型纳米复合物药物在临床前小鼠模型中表现出显著的治疗疗效.

结论:

合成的Au/Doc/Quer@PDA/A10-3.2NP代表了克服前列腺癌中多塞素耐药性的有希望的策略.
这种新型纳米复合物药物具有临床应用的潜力,用于治疗先进和耐药的PC形式.

关键词:

前列腺癌是什么意思前列腺癌是什么意思癌症恶性表型癌症恶性表型化学疗法化疗化疗纳米药物载体载体是什么青素 (Quercetin) 是一种青素.

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