老年人具有不同程度的认知功能,具有独特的下微生物特征
Lili Chen1,2, Xiuli Li3, Jinxiu Liu3
1Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Journal of clinical periodontology
|May 21, 2024
概括
下微生物特征与老年人的认知能力下降有关. 口腔细菌的变化可能作为认知障碍的生物标志物,需要进一步的诊断研究.
科学领域:
- 口腔微生物学 口腔微生物学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 包括痴呆症在内的认知障碍是老年人群中日益严重的公共卫生问题.
- 口腔微生物群,特别是下微生物群,在全身健康中起着重要作用.
- 新出现的证据表明,口腔健康和神经疾病之间存在联系.
研究的目的:
- 研究 subgingival 微生物组成与老年人不同程度的认知功能之间的关联.
- 识别与认知衰退相关的特定细菌特征,从主观认知衰退到痴呆.
- 探索口腔微生物群作为认知障碍生物标志物的潜力.
主要方法:
- 分析了165名参与者从四个组的下斑块样本和16SrRNA测序:正常对照组,主观认知衰退,轻度认知障碍和痴呆症.
- 跨认知群体的细菌丰富和微生物社区组成的比较.
- 应用随机森林模型来评估下菌群对认知障碍的诊断能力.
主要成果:
- 较低的细菌丰富度与较差的认知功能相关.
- 在四个认知组中观察到下微生物群落的显著差异.
- 特定的属 (例如,Porphyromonas) 增加,而其他 (例如,Capnocytophaga,Lautropia) 随着认知能力下降而下降. 一个随机森林模型在区分认知障碍与正常对照时取得了高准确度 (AUC=0.933).
- 口腔微生物群与认知得分 (MoCA,MMSE) 和性别有显著的相关性. 莱普托里奇亚和伯克霍尔迪亚与MoCA得分有负相关性.
结论:
- 这项研究提供了第一个证据,将下微生物群的组成,功能和代谢途径与老年人认知功能的不同阶段联系起来.
- 这一发现表明,下微生物特征可能作为潜在的认知障碍诊断指标.
- 建议进行进一步的纵向队列研究,以验证这些口腔微生物特征的诊断效用.
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