相关实验视频

Updated: Jun 25, 2025

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

Published on: February 7, 2021

[免疫检查点抑制剂在非小细胞肺癌中的伪进展]

Yajun Tong¹, Yong Long², Fan Zhang²

¹Department of Oncology, Yueyang Central Hospital, Yueyang 414000, China.

Zhongguo fei ai za zhi = Chinese journal of lung cancer

|May 21, 2024

概括

免疫检查点抑制剂 (ICI) 改善了晚期肺癌的结果,但可能导致伪进展 (PsP). 早期的PsP诊断和预测因素仍然是瘤学家面临的挑战.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了晚期肺癌的治疗方法.
伪进展 (PsP) 是ICI治疗的一个具有挑战性的并发症,其特征是暂时瘤扩大或新的病变.
准确的早期诊断和对PsP机制的理解目前是有限的.

研究的目的:

审查ICI治疗的非小细胞肺癌 (NSCLC) 患者伪进展的当前研究状况.
为治疗PsP的瘤学家提供临床策略.

主要方法:

用ICI治疗的NSCLC中PsP研究的文献综述.
对诊断挑战,机制,预测因素和生物标志物的分析.

主要成果:

在成像上,PsP可以模仿瘤的进展,使治疗决策复杂化.
随着持续的ICI治疗,经常观察到成像的改善,通常没有临床恶化.
缺乏明确的预测因素和可靠的生物标志物阻碍了早期的PsP识别.

结论:

在NSCLC中有效管理PsP需要对其潜在机制有更深入的了解.
对预测因素和生物标志物的进一步研究对于准确的早期诊断和优化临床策略至关重要.
本综述旨在为瘤学家提供当前知识,以有效应对PsP挑战.

关键词:

免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.肺部瘤是什么肺部瘤伪进步是一种伪进步.

更多相关视频

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.