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剂量计和NTCP分析用于选择腺癌患者进行质子疗法

Anna Maria Camarda^1,2,3, Maria Giulia Vincini², Stefania Russo⁴

¹Radiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy, Pavia, Italy.

|May 21, 2024

概括

强度调制质子疗法 (IMPT) 对腺癌的体积调制弧线疗法 (VMAT) 具有剂量学优势. 几乎三分之一的患者可能会从IMPT中受益,特别是在预防听力损失和耳.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

腺癌需要精确的放射治疗来最大限度地减少副作用.
比较强度调制质子疗法 (IMPT) 和体积调制弧线疗法 (VMAT) 对于优化治疗计划至关重要.

研究的目的:

为了对比IMPT和VMAT之间的剂量测量和正常组织并发症概率 (NTCP) 结果,用于腺癌患者.
评估IMPT在降低该患者队列中毒性的潜在好处.

主要方法:

在2011年5月至2021年9月期间治疗的37名腺癌患者的回顾性分析.
风险器官 (OAR) 的轮和生成IMPT和VMAT治疗计划.
对六种已建立的模型进行NTCP计算和比较.

主要成果:

与VMAT相比,IMPT在大多数OAR中实现了统计学上显著较低的平均剂量 (Dmean).
大约27%的患者在光子和质子计划之间显示了NTCP对于听力损失和耳的>10%差异.
大多数受益于IMPT的患者是患有听力损失和耳风险较高的患者.

结论:

相当一部分腺癌患者是质子治疗的候选人.
与VMAT相比,IMPT显示出优越的剂量测量概况和降低特定毒性 (如听力损失和耳) 的潜力.

关键词:

在NTCP模型中,强度调节的质子疗法强度调节的质子疗法腺癌腺癌腺癌患者的选择患者的选择

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