NF-κB/FXR/TonEBP通路保护脏髓间歇细胞免受高血压的压力
Chunxiu Du1,2, Shuyuan Hu3, Yaqing Li4
1Wuhu Hospital, East China Normal University, Wuhu, Anhui, China.
Journal of cellular and molecular medicine
|May 21, 2024
概括
核因子-kappa B (NF-κB) /Farnesoid X受体 (FXR) /调度响应增强结合蛋白 (TonEBP) 途径保护髓间歇细胞 (RMICs) 在高调压力下免受细胞死亡. 这条通路对于髓中的细胞存活至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 法尔内索伊德X受体 (FXR) 通过脏中的水二 (AQP2) 调节水的平衡.
- 在高血压条件下,FXR在髓间歇细胞 (RMIC) 生存中的作用尚不清楚.
研究的目的:
- 调查FXR在高血压压力下RMIC生存中的作用.
- 阐明RMICs的FXR介导保护的基础分子机制.
主要方法:
- 主要小鼠RMICs被培养并受到高压的压力.
- 分析了FXR表达,NF-κB与FXR促进体结合以及TonEBP通路激活.
- 在FXR激活或抑制后评估了细胞活力.
主要成果:
- 在RMICs中高压压力上调调节的FXR表达.
- NF-κB与FXR基因促进体结合并激活它.
- FXR激活保护RMICs免受高血压引起的细胞死亡.
- FXR增强了TonEBP表达和核转位,增加了SMIT和HSP70表达.
结论:
- NF-κB/FXR/TonEBP信号通路为RMIC提供了对高压的保护.
- 这一途径对于在高血压环境中维持髓细胞存活至关重要.
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