可注射,自我愈合和可降解的动态水凝具有可调节的机械性能和通过热诱导的化稳定性
Chunqing Lin1, Leniu Chen1, Yuan He1
1College of Chemistry, Chemical Engineering and Environmental Science, Minnan Normal University Zhangzhou 363000 PR China guozanru@mnnu.edu.cn nieyujing@mnnu.edu.cn.
RSC advances
|May 21, 2024
概括
新的动态水凝为生物医学应用提供可调节的机械性能和稳定性. 这些可注射和自我愈合的材料显示出作为药物载体和组织工程支架的前景.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
背景情况:
- 动态水凝对于生物医学应用至关重要,但往往缺乏可调整的机械性能和稳定性.
- 传统的动态水凝在精确控制其物理和化学特性方面面临着挑战.
研究的目的:
- 合成新型ABA-triblock共聚合物,以创建可调和稳定的动态水凝.
- 研究这些生物医学用水凝的可注射,自我愈合,可降解和反应性质.
主要方法:
- 合成的ABA-triblock共聚合物使用RAFT聚合与热敏感的A块和水友B块.
- 通过共聚合物和亚酸二化物 (ADH) 之间的亚化物键形成动态基.
- 评估了水凝特性,包括可注射性,自我愈合性,机械强度,低pH稳定性,可降解性,细胞相容性和药物释放性.
主要成果:
- 合成的水凝表现出可注射和自我愈合的特性.
- 热敏块的热诱导化增强了机械强度和稳定性 (即使在pH值为2.0).
- 水凝显示了多克索鲁比 (DOX) 的受控释放和良好的细胞相容性.
- 降解是通过三碳酸盐组的破裂来实现的.
结论:
- 开发的动态水凝具有可调节的机械性能,增强的稳定性和受控的降解.
- 这些水凝具有重要的生物医学应用潜力,包括药物输送和组织工程支架.
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