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聚多巴胺修饰黑纳米板药物输送系统用于治疗缺血性中风

Shujiang Yin¹, Jing Hou¹, Jie Li¹

¹Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy, Shihezi University, Shihezi 832002, China.

Regenerative biomaterials

|May 21, 2024

概括

这项研究开发了一种稳定的黑药物输送系统,BP-Pte@PDA,通过穿越血脑屏障来治疗缺血性中风. 该系统有效地减少了小鼠中风损伤和炎症.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
神经科学是一个神经科学.

背景情况:

黑 (BP) 纳米薄膜提供高药载荷,生物相容性和生物降解性.
高血压的光热效应增强了血脑屏障 (BBB) 的透性,这对于治疗缺血性中风 (IS) 至关重要.
由于BP固有的不稳定性,实际应用需要对其表面进行修改.

研究的目的:

开发一种稳定的,穿透BBB的药物输送系统,用于治疗缺血性中风.
为了提高治疗效果,使用载入改性黑纳米片 (BP-Pte@PDA) 的 (Pte) 来提高治疗效果.
为了评估系统的稳定性,BBB穿越和治疗效果在缺血性中风小鼠模型中.

主要方法:

合成的多多巴胺 (PDA) 修饰的黑色纳米片装载着聚乙烯 (BP-Pte@PDA).
研究了系统的稳定性,通过光热效应透到BBB,以及对刺激有反应的药物释放 (pH和近红外).
在中脑动脉封闭 (MCAO) 鼠标模型中评估治疗疗效,评估心脏病发作大小,脑水含量,神经功能,炎症和亡.

主要成果:

该BP-Pte@PDA系统表现出强大的稳定性和有效的BBB透.
治疗显著减少了心脏病发作的大小,大脑水含量,并改善了MCAO小鼠的神经缺陷.
该系统抑制了TLR4炎症因子表达,并减少了细胞亡,这表明它具有强大的抗炎和神经保护作用.

结论:

新型BP-Pte@PDA药物输送系统表现出优异的稳定性,生物相容性和治疗性疗效.
该系统克服BBB限制和向炎症的能力为临床IS治疗提供了有前途的方法.
这项研究强调了表面修饰黑纳米材料在先进的药物输送应用中的潜力.

关键词:

黑色的纳米薄膜.血脑屏障血脑屏障血脑屏障血脑屏障缺血性中风中风的pH值响应的pH值响应.聚多巴胺胺是一种多多巴胺胺.

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