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鼻子背后的科学:将挥发性有机化合物特征与犬类COVID-19生物检测相关联

Marthe Charles1,2, Dorota Ruszkiewicz2,3, Eric Eckbo1,2

  • 1Division of Medical Microbiology, Vancouver Coastal Health, Vancouver, BC, Canada.

ERJ open research
|May 21, 2024
PubMed
概括

通过气体染色体质谱法 (GC-MS) 验证了COVID-19 (2019年冠状病毒疾病) 的狗气味检测. 这项研究证实,训练辅助物释放出特定的挥发性有机化合物 (VOC),狗可以检测到它们,帮助识别COVID-19.

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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...