基于便的儿童结核检测的诊断准确性,可行性和可接受性
Bazezew Yenew1,2, Petra de Haas3,2, Yohannes Babo4
1Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
ERJ open research
|May 21, 2024
概括
使用Xpert-Ultra的简单单一步 (SOS) 便试验是诊断儿童结核病 (TB) 的可行的替代方案,当呼吸道样本无法获得时. 这种方法是可行的,可接受的护理人员,并为儿童结核病提供了良好的诊断准确性.
科学领域:
- 儿童传染病 儿童传染病
- 诊断微生物学 诊断微生物学
- 分子诊断学 分子诊断学
背景情况:
- 儿童结核病 (TB) 诊断是具有挑战性的,因为儿童无法产生唾液.
- 目前用于儿童结核病的诊断方法可能是侵入性的或缺乏足够的准确性.
- 需要对儿童结核病进行非侵入性,准确的诊断工具.
研究的目的:
- 为了评估简单的一步 (SOS) 便方法与Xpert MTB/RIF Ultra (Xpert-Ultra) 治疗儿童结核病的诊断准确性.
- 为了比较SOS便方法的性能与培养,呼吸道样本 (RS) 的Xpert-Ultra和临床诊断.
- 评估便检测的可行性和可接受性以及护理人员的偏好.
主要方法:
- 埃塞俄比亚的儿童 (≤10岁) 据推测患有肺结核病.
- 使用Xpert-Ultra和培养检测了呼吸道样本 (RS).
- 使用SOS便方法与Xpert-Ultra分析了便样本.
主要成果:
- 在SOS便Xpert-Ultra方法显示了69.1% (vs.培养),76.8% (vs.RSXpert-Ultra) 和59.0% (vs.临床诊断) 的灵敏度.
- 在所有比较中,特异性很高 (≥98.8%).
- 实验室工作人员发现便收集是可行的,SOS方法很容易执行;75%的护理人员更喜欢便测试.
结论:
- SOS便Xpert-Ultra测试是诊断儿童结核病的有价值的替代方案,儿童无法提供唾液.
- 这种非侵入性方法可以避免需要进行侵入性手术以获得呼吸道样本.
- 该测试的可行性,可接受性和良好的特异性支持其在儿科结核病诊断中的使用.
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