关键透皮贴片使用含有大麻素的纳米载体,在体内具有更好的药理动力学
Po-Cheng Chu1,2, Man-Hua Liao3, Mao-Gu Liu1
1Department of Chemistry, National Chung Hsing University, Taichung, Taiwan.
International journal of nanomedicine
|May 21, 2024
概括
这项研究开发了一种新的通过皮肤递送药物系统,使用状囊泡纳米载体来改善大麻素 (CBD) 的生物可用性. 与口服和免费CBD应用相比,新的CBD纳米载体补丁显著提高了药物吸收.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 大麻二醇 (CBD) 显示出治疗前景,但具有较差的溶解性和较低的口服生物利用性.
- 透皮药物输送系统 (TDDS) 提供了一种替代途径,可以克服CBD的药物动力学限制.
- 状膀纳米载体为增强药物输送提供了一种创新的策略.
研究的目的:
- 开发一种通过皮肤贴片,结合状囊泡纳米载体,以改善CBD的输送.
- 通过一种新的透皮纳米载体系统,提高CBD的生物可用性和治疗效果.
- 为了应对CBD溶解性差和口服生物可用性低的挑战.
主要方法:
- 状囊状纳米载体 (CTD-12) 用纳米乳液方法制备,其特点是颗粒体大小小和高封装效率.
- 在24小时内使用Strat-MTM膜和通过皮肤扩散系统进行了皮肤透研究.
- 在老鼠中进行了初步的药理动力学研究,使用开发的透皮纳米载体贴 (PCTD-12).
主要成果:
- 与自由CBD相比,CTD-12通过皮肤应用显示相对生物利用率增加了3.68倍.
- 载有CBD的透皮纳米载体补丁 (PCTD-12) 在体外评估中显示相对生物利用率是免费CBD补丁的2.46倍.
- 在药理动力学研究中,PCTD-12的相对生物利用率与口服CBD的相比高出9.47倍.
结论:
- CTD-12是一种通过皮肤的纳米载体配方,有效地提高了CBD的生物可用性.
- 开发的透皮纳米载体药物补丁显示了改善CBD治疗结果的巨大潜力.
- 这种创新的TDDS方法为有效的CBD输送提供了一个有希望的解决方案.
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