固体瘤中EIF5A2的预测值:一个元分析和生物信息学分析
Jianwen Fang1, Tianze Yu1, Xiaocong Jiang1
1Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Open medicine (Warsaw, Poland)
|May 21, 2024
概括
细胞转化启动因子5A2 (EIF5A2) 的过度表达与许多癌症的生存率低下有关. 这项研究证实EIF5A2是可靠的预后生物标志物,用于预测癌症结果和患者存活率.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症基因组学 癌症基因组学
背景情况:
- 异常过度表达的真核转化启动因子5A2 (EIF5A2) 与癌症的预后不佳有关.
- EIF5A2在促进转移性进展方面发挥着至关重要的作用.
- EIF5A2被认为是各种恶性瘤的潜在预后生物标志物.
研究的目的:
- 阐明EIF5A2作为癌症结局预测的预后生物标志物的有用性和意义.
- 评估EIF5A2在固体瘤中的预后价值.
- 评估EIF5A2作为癌症预测标记物的有效性.
主要方法:
- 在PubMed,EMBASE和Web of Science数据库中进行了全面的文献搜索.
- 进行了元分析,以检查EIF5A2和生存预后之间的关联,使用危险比率和95%置信区间.
- 癌症基因组图谱 (TCGA) 和基因表达特征交互分析 (GEPIA) 数据库被用于验证EIF5A2表达及其与不同癌症类型患者结果的相关性.
主要成果:
- 聚合分析显示,EIF5A2表达的增加与总生存率 (OS) 和无疾病生存率/无进展生存率/无复发生存率 (DFS/PFS/RFS) 的下降显著相关.
- 在27种癌症类型中,TCGA数据显示了EIF5A2的显著上调,在特定癌症亚型中,过度表达与更短的OS,更糟糕的DFS和更糟糕的PFS有关.
- GEPIA的分析进一步证实,EIF5A2过度表达与减少的OS和DFS有关.
结论:
- 在固体瘤中,EIF5A2被验证为可靠的预后标志物.
- 分析证实了EIF5A2在预测各种固体恶性瘤患者存活率方面的显著预后价值.
- EIF5A2证明了作为癌症预后预测标记物的有效性.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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