胃肠神经内分泌瘤的内镜和手术治疗:基于人口的比较研究
1Department of Gastroenterology, Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City, Changshu, Jiangsu, China.
概括
内镜治疗 (ET) 和手术为胃肠神经内分泌新生瘤 (GI-NENs) 提供类似的长期存活率. 在早期或小型瘤和结肠中,ET可能是更好,显示出更好的结果.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 对肠道神经内分泌新生瘤 (GI-NENs) 的内镜治疗 (ET) 和手术的适应性仍在争论中.
- 本研究将ET和GI-NENs的外科手术之间的长期生存结果进行比较.
研究的目的:
- 在被诊断为胃肠神经内分泌瘤 (GI-NENs) 的患者中,比较内镜治疗 (ET) 和手术之间的长期生存预后.
主要方法:
- 从SEER数据库 (2000-2020年) 中对12,016名GI-NEN患者进行了回顾性分析.
- 卡普兰-梅尔方法用于整体存活率 (OS) 和癌症特异性存活率 (CSS) 估计.
- 倾向性得分匹配 (PSM) 调整临床变量和考克斯回归用于预后因素评估.
主要成果:
- 在PSM后的ET和手术组之间,在OS和CSS中没有显著差异.
- 亚组分析表明,在I阶段和小于10毫米的瘤中,CSS与ET更好.
- 与手术相比,ET在结肠子组中表现出优异的OS和CSS.
结论:
- 内镜治疗和手术显示,GI-NENs的长期存活预后相似.
- 对于那些希望避免手术的患者来说,ET是一种可行的替代方案.
- 在特定的子组中,ET可能会提供更好的结果,包括早期疾病和结肠NEN.
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