药物负担指数在老年住院患者中发生的变化与未发生的患者之间的比较:一项病例对照研究
Claire E T O'Leary1, Timothy J Wilkinson1,2, H Carl Hanger1,2
1Older Persons Health, Te Whatu Ora (Health New Zealand)-Waitaha, Burwood Hospital, Christchurch, New Zealand.
Australasian journal on ageing
|May 21, 2024
概括
住院的老年人经常跌倒,这增加了镇静剂和抗胆固醇药物的负担. 这项研究发现,在入院期间,药物负担对失败者或非失败者的药物负担没有临床显著的减少.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 患者安全 患者安全
背景情况:
- 老年住院患者的跌倒很常见,通常与脆弱性,并发病症和多药性有关.
- 镇静剂和诱发狂妄的药物是已知的风险因素,导致在这个人群中跌倒.
- 了解药物负担的变化对于预防跌倒的策略至关重要.
研究的目的:
- 为了比较老年住院患者的镇静剂和抗胆固醇药物负担 (药物负担指数 - DBI) 的变化,这些患者跌倒与没有跌倒的人相比.
- 确定与住院期间药物负担变化相关的因素.
主要方法:
- 一项回顾性,观察性,病例对照研究,比较了200名失败者和200名非失败者.
- 收集的数据包括人口统计,功能能力,脆弱性,认知和药物细节.
- 药物负担指数 (DBI) 计算了所有参与者的入院和出院情况.
主要成果:
- 与非失败者相比,失败者在入院和出院时表现出更高的DBI (p < .001).
- 在入院和出院之间,在两组中都观察到DBI的轻微,非临床显著的下降.
- 较高的初始药物计数和DBI药物与更大的DBI变化有关.
结论:
- 尽管已知老年患者服用镇静剂/抗胆固醇药物的风险,但这项研究没有发现在住院期间平均DBI的临床显著降低.
- 需要进一步的研究来开发有效的干预措施,以减少药物负担和预防住院老年人的跌倒.
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