已出院的COVID-19患者的快速肺129Xe通风MRI,采用曲采样
Yuan Fang1,2, Haidong Li2,3, Luyang Shen2
1School of Physics, Huazhong University of Science and Technology, Wuhan, China.
Magnetic resonance in medicine
|May 21, 2024
概括
采用梯度召唤回声序的齐格扎格采样使得3D超极化129Xe肺透气的MRI能够快速实现. 这种技术可以显著减少扫描时间,同时保持高图像质量和准确的通风缺陷百分比量化.
科学领域:
- 医疗成像医学成像
- 肺部医学 肺部医学
- 磁共振成像技术 磁共振成像技术
背景情况:
- 超极化129XeMRI是评估肺呼吸的强大工具.
- 传统的MRI序列可能耗时,限制了临床适用性.
- 需要快速成像技术来提高患者的舒适性和吞吐量.
研究的目的:
- 为了评估3D快速超极化129Xe通风MRI的可行性,在人类中使用齐克扎克采样.
- 为了比较图像质量和数量指标之间的齐克扎克和传统的MRI序列.
主要方法:
- 开发了一个渐变回忆的回声序列,采用了曲采样 (GRE-zigzag-Y和GRE-zigzag-YZ).
- 在健康志愿者和COVID-19幸存者中获得了129Xe通风图像.
- 使用结构相似度指数和Dice系数比较图像质量.
- 量化通风缺陷百分比 (VDP) 和测定序列之间的一致性.
主要成果:
- GRE-zigzag-Y在2.2秒内实现了3.96×3.96×10.5毫米3分辨率的图像,而bSSFP则是10.5秒,图像相似度很高 (0.85).
- GRE-zigzag-YZ在5.5秒内获得了2.5毫米的同位素分辨率图像.
- 来自GRE-zigzag-YZ的VDP测量与bSSFP有很强的相关性 (R2=0.93),显示最小偏差.
结论:
- 结合GRE序列的齐格扎格采样,可以快速进行129Xe通风成像.
- 这种方法为临床肺部MRI提供了一种可行和高效的方法.
- 该技术提供了准确的VDP量化,对肺部疾病的评估有价值.
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