前海马和后海马的功能连接的专业化在自闭症中不同
J Kember1, P Patenaude1, H Sweatman1
1Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
概括
自闭症谱系障碍 (ASD) 显示了海马-皮质连接的改变,影响了记忆和社会技能. 这项研究揭示了ASD个体的海马体前后专业化较弱,这表明有发展差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 认知科学 认知科学
背景情况:
- 自闭症谱系障碍 (ASD) 与情节性记忆和社会障碍有关.
- 海马 - 皮层功能连接显示神经类型发育前后专业化.
- 在ASD中的这种专业化和其发展轨迹中出现的干扰并未得到充分理解.
研究的目的:
- 为了调查与神经类型对照相比,ASD患者的前后海马-皮质连接性差异.
- 检查ASD组内这种连接专业化的与年龄相关的变化.
主要方法:
- 来自健康大脑网络 (HBN) 的休息状态功能磁共振成像 (fMRI) 数据来自139名自闭症患者和133名对照人群 (5-21岁).
- 分析前后海马和皮质区域之间的功能连接,包括中间前额叶皮质,后额叶皮质和前皮质.
主要成果:
- 患有自闭症的个体表现出较低的整个海马-中枢前额叶皮层连接.
- 在ASD中观察到,后海马与对记忆敏感的后壁皮质皮质区域的偏好连接性减少,这表明前后专业化较弱.
- 后 hippocampus-precuneus 连接在ASD组中显示出与年龄的负相关性,与对照组中稳定的连接不同,表明发育轨迹发生了变化.
结论:
- 自闭症的特点是海马-皮质连接的改变,特别是较弱的前后专业化.
- 这些连接性差异,特别是改变的发育轨迹,可能是自闭症患者记忆和社会缺陷的基础.
- 这些发现强调了研究ASD中大脑连接的发育变化的重要性.
关键词:
前部/后部 在前部/后部自闭症谱系障碍 (ASD)发展发展发展发展发展.这是一种情节性记忆 (episodic memory).在海马体内,海马体纵向轴的纵向轴是一个直线.中部前额叶皮层中部前额叶皮层静止状态的功能连接性更多相关视频
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