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抗氧化剂欧戈氨酸可以通过Nrf2通路缓解西斯普拉丁引起的听力损失
Wenji Zhao1,2,3, Fan Wu1,4,2,3, Rui Hu1,5,2,3
1Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Antioxidants & redox signaling
|May 21, 2024
概括
埃尔戈氨酸 (EGT) 通过减少活性氧物种 (ROS) 和激活Nrf2通路来保护对抗西斯胺诱导的听力损失 (CIHL). 这表明EGT可能是预防化疗相关耳毒性的新疗法.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 耳部毒理学 耳部毒理学
背景情况:
- 西斯丁 (CDDP) 是一种用于治疗头和部瘤的化疗药物.
- CDDP治疗经常导致耳毒性,与内耳反应性氧物种 (ROS) 有关.
- 欧戈氨酸 (EGT) 以其抗氧化特性而闻名.
研究的目的:
- 调查EGT对西斯普拉丁诱导的听力损失 (CIHL) 的保护作用.
- 阐明EGT预防CIHL的作用的基本机制.
主要方法:
- 在实验室和体内使用CDDP治疗小鼠的研究.
- 听觉脑干反应 (ABR) 门转移测量.
- 评估ROS的产生,亲细胞突变蛋白和Nrf2通路的激活.
- 对尾中SLC22A4 (OCTN1) 表达的分析.
主要成果:
- EGT显著减轻了CDDP诱导的耳毒性,减少了ABR值转移30dB.
- EGT抑制了ROS的产生和前性蛋白质的表达.
- EGT的保护作用通过Nrf2通路进行介导.
- 一个EGT载体的SLC22A4 (OCTN1) 存在于尾细胞中.
结论:
- 通过激活Nrf2/HO-1/NQO-1通路并减少氧化应激,EGT可以预防CIHL.
- EGT在耳感官毛细胞中维持氧化还原稳定.
- EGT显示出作为一种新型治疗剂的潜力,可以缓解化疗引起的听力损失.
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