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Updated: Jun 25, 2025

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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在CD4+T细胞中,EBI2受体与CCR5共同表达,并促进HIV-1R5复制

Adeline Guigues1, Sandrine Gimenez1, Clément Mettling1

  • 1Institut de Génétique Humaine, CNRS-Université de Montpellier UMR9002.

AIDS (London, England)
|May 21, 2024
PubMed
概括

爱斯坦-巴尔病毒诱导的基因2 (EBI2) 通过促进病毒进入和复制,增强了CD4+ T细胞中的HIV-1 R5感染. 准EBI2可能会减少治疗患者的持续性HIV复制.

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Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
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