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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

6.2K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.2K
Principles of Drug Action01:24

Principles of Drug Action

6.0K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
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Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
570
Drug Therapy01:28

Drug Therapy

42
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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相关实验视频

Updated: Jun 25, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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COVID-19 的治疗方法.

Daniele Focosi1, Massimo Franchini2, Fabrizio Maggi3

  • 1North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.

Clinical microbiology reviews
|May 21, 2024
PubMed
概括
此摘要是机器生成的。

本综述审查了COVID-19抗病毒疗法,包括它们的疗效,安全性和机制. 它强调了对高风险患者的治疗选择和为新药开发提供资金的持续挑战.

关键词:
在 COVID-19 疫情中,这就是SARS-CoV-2病毒.抗病毒疗法 抗病毒疗法康复期间的血.一个单克隆抗体.小分子抗病毒药物.

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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

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相关实验视频

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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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科学领域:

  • 传染性疾病 传染性疾病
  • 药理学 药理学是指药理学的学科.
  • 病毒学 病毒学

背景情况:

  • 由于COVID-19的流行,需要快速开发抗病毒疗法.
  • 目前的治疗选择面临的挑战是由于病毒的演变和有争议的疗效.
  • 对于高风险个体的最佳疗法,仍然存在不确定性.

研究的目的:

  • 审查COVID-19抗病毒疗法的抗病毒活性,作用机制,药理动力学和安全性.
  • 总结这些抗病毒药物的疗效和安全性随机对照试验的证据.
  • 讨论COVID-19抗病毒药物开发的未满足需求.

主要方法:

  • 关于COVID-19抗病毒疗法的综合文献综述.
  • 对随机对照试验 (RCT) 数据的分析.
  • 对药物动力学和安全性概况的评估.

主要成果:

  • 已经研究了多种抗病毒药物,具有不同程度的疗效和安全性.
  • 病毒的进化对治疗的有效性构成了重大挑战.
  • 药物管道面临资金短缺和发展疲劳.

结论:

  • 需要进一步的研究来优化COVID-19治疗策略,特别是在高风险人群中.
  • 解决未满足的抗病毒开发需求对于未来的流行病准备至关重要.
  • 对现有和新型抗病毒药物的持续评估至关重要.