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An R-Based Landscape Validation of a Competing Risk Model
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通过模型效率和合适性,为三个状态瘤学成本效益模型提供结构假设的信息
1Health Economics & Decision Sciences, Merck & Co., Inc., Rahway, NJ, 07065, USA. dominic.muston@merck.com.
Applied health economics and health policy
|May 21, 2024
概括
本研究介绍了方法和R软件,用于比较分区生存模型 (PSMs) 和状态过渡模型 (STMs) 的瘤学成本效益. 在试验数据分析中,STM时钟重置结构表现出卓越的适应性和效率.
科学领域:
- 卫生经济学 卫生经济学
- 数学建模的数学建模
- 在瘤学瘤学.
背景情况:
- 分区生存模型 (PSM) 和状态过渡模型 (STM) 用于瘤学成本效益,但模型选择往往缺乏明确的理由.
- 现有的经济建模指南强调基于疾病,数据和决策问题的结构选择,但很少比较多个结构.
- 缺乏工具阻碍了对不同结构选择的模型合适性和效率等内部有效性指标的评估.
研究的目的:
- 介绍方法和R软件包 (psm3mkv) 用于评估不同模型结构的合适性和效率.
- 解决成本效益分析中用于比较模型结构的工具的缺口.
- 帮助建模人员评估结构性不确定性和敏感性.
主要方法:
- 对三个不同的模型结构的模型适合性和效率的评估.
- 使用KEYNOTE-826随机对照试验中期和最终分析数据集的方法的应用.
- 使用附带的R软件包psm3mkv进行分析.
主要成果:
- 状态过渡模型 (STM) 时钟重置结构在中间和最终分析中表现出最佳和最有效的适应性.
- 从中期分析到最终分析,结构性不确定性减少了.
- 开发的方法有助于更容易地评估和报告模型适合性和效率.
结论:
- 对于基于适应性和效率的分析瘤学成本效益模型,建议使用STM时钟重置结构.
- 所介绍的方法和软件增强了评估内部有效性和结构假设的能力.
- 建模人员可以更好地评估结构选择,隐含假设和敏感性,与健康经济建模的最佳实践保持一致.
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