最近在注意力缺陷/多动障碍的药理管理方面取得的进展:超越兴奋剂
1Center for Psychiatry and Behavioral Medicine, Inc, Las Vegas, NV, USA.
Expert opinion on pharmacotherapy
|May 21, 2024
概括
新的非刺激药物为注意力缺陷/多动障碍 (ADHD) 治疗提供了替代方案. 这些选择可能会改善因副作用或缺乏疗效而停止传统兴奋剂药物治疗的个体的坚持.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 儿童和成人精神病学
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种普遍存在的神经行为障碍,影响儿童和成人.
- 目前的ADHD治疗主要涉及兴奋剂药物,这些药物具有潜在的副作用和滥用风险.
研究的目的:
- 审查用于ADHD治疗的可用的非刺激药物.
- 讨论临床试验中新兴的非刺激性化合物.
主要方法:
- 对FDA批准的非刺激性ADHD药物的审查.
- 非兴奋剂的疗效和安全性数据的摘要.
- 在第三阶段临床试验中的非刺激药物的概述.
主要成果:
- 亚托莫克西丁和维洛克萨辛ER已被批准用于儿童和成人;克洛尼丁ER和关法辛ER已被批准用于儿科.
- 一些新的非刺激性化合物,包括百纳法丁,solriamfetol和L-threonic酸盐,正在第三阶段试验中.
- 高停药率 (儿童超过33%,成人超过50%) 凸显了需要替代性ADHD治疗的必要性.
结论:
- 非刺激药物为ADHD管理提供了关键的替代品.
- 新的非刺激药物开发为改善治疗坚持和耐受性提供了希望.
- 解决个体药物反应和耐受性是长期ADHD治疗成功的关键.
关键词:
更多关于 ADHD ADHD 的文章亚托莫克西丁 (atomoxetine) 是一种药物.注意力缺陷/多动症障碍.百纳法丁 (Centanafadine) 是一种百纳法丁 (Centanafadine) 的一种药物.克洛尼迪因 (clonidine) 是一种类型的药物.瓜恩法西尼 (guanfacine) 是一种没有刺激的非刺激剂.维洛克萨辛 (Viloxazine) 是一种更多相关视频
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