患有尿路感染的糖尿病患者的败血症风险
Sipei Wang1, Sheng Zhao1, Shanshan Jin1
1Department of Clinical Laboratory, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang, Zhejiang, China.
PloS one
|May 21, 2024
概括
患有尿路感染 (UTI) 的糖尿病患者有败血症的风险. 专蛋白,C反应蛋白和白细胞计数可以帮助在这些患者中早期检测出败血症.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 尿路感染 (UTI) 在糖尿病患者中很常见.
- 糖尿病患者的尿道感染可以发展为严重的败血症,需要进行危险因素分析.
- 在糖尿病尿路感染中确定败血症预测因子对于及时干预至关重要.
研究的目的:
- 分析患有尿路感染的糖尿病患者败血症的风险变量.
- 在这个人群中确定早期毒症检测的关键生物标志物.
主要方法:
- 在2011-2022年期间,对1919名糖尿病患者进行了回顾性横截面分析,这些患者患有尿路感染.
- 收集尿液和血液培养的数据,分为败血症和非败血症组.
- 单变量和多变量回归分析以确定风险因素.
主要成果:
- 在13.97%的患者 (268/1919) 中发现了败血症.
- 主要的败血症预测因素包括低白蛋白 (ALB <34.35 g/L),高C反应蛋白 (CRP>55.84 mg/L) 和白细胞数量升高 (WBC>8.485 X 10^9/L).
- 对ALB,CRP和WBC的综合分析显示,对于败血症预测,ROC曲线下的区域为0.809.
结论:
- 在糖尿病尿路感染中早期检测败血症是可行的,通过CRP,WBC和ALB的综合分析.
- 这些生物标志物为风险分层和及时管理提供了有价值的工具.
- 进一步的研究可以完善糖尿病人群中败血症的预测模型.
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