在炎症性肠道疾病中心力衰竭的风险:瑞典基于人口的研究
Jiangwei Sun1, Jialu Yao1, Ola Olén2,3,4
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
European heart journal
|May 21, 2024
概括
与一般人群相比,患有炎症性肠病 (IBD) 的个人在诊断后的20多年内面临心力衰竭 (HF) 的风险中适度增加.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症和免疫失调与心力衰竭 (HF) 病原发生有关.
- 炎症性肠病 (IBD) 患者的高风险在很大程度上是未知的.
- IBD包括克罗恩病 (CD),性结肠炎 (UC) 和IBD未分类 (IBD-U).
研究的目的:
- 调查IBD与发展HF的风险之间的关联.
- 量化IBD患者的长期HF风险与一般和兄弟对照相比.
主要方法:
- 瑞典一项全国性队列研究在1969-2017年间确定了81,749名IBD患者 (CD,UC,IBD-U).
- IBD患者与一般人群和IBD免费的兄弟对照进行了匹配.
- 灵活的参数生存模型估计了HF风险的危险比率 (aHR).
主要成果:
- 在IBD患者中,HF的发病率较高 (50.3/10,000人/年),而不是参考人群 (37.9).
- 在IBD患者中,HF的调整后危险比为1.19 (95% CI 1.15-1.23),持续超过20年.
- 在所有IBD亚型 (CD,UC,IBD-U) 中观察到HF风险增加.
结论:
- 患有IBD的患者患心力衰竭的风险中等.
- 这种增加的风险在IBD诊断后至少持续20年.
- 这些发现强调了IBD患者心血管监测的重要性.
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