Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Membrane Fluidity01:23

Membrane Fluidity

152.1K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
152.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Acute cognitive effects of interruptions to prolonged sitting with brief standing or physical activity breaks: a systematic review and three-level meta-analysis.

The international journal of behavioral nutrition and physical activity·2026
Same author

[Effect of RNA Sequencing Normalization on Forensic Age Estimation].

Fa yi xue za zhi·2026
Same author

Air-permeable hydrogels through viscoelastic phase separation of aerogels.

Nature·2026
Same author

Structural mechanisms for self-activation of protease-activated receptor 4 by tethered ligand.

Cell reports·2026
Same author

Bidirectional longitudinal associations of family/friend social support with cognitive function in late life.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same author

Clinical Patterns and Appropriateness of Apixaban Dosing in Patients With Atrial Fibrillation.

JACC. Advances·2026

相关实验视频

Updated: Jun 25, 2025

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
10:43

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Published on: February 9, 2018

47.3K

聚糖的功能化减少了脂质囊泡的硬度.

Kevin Jahnke1, Marko Pavlovic1, Wentao Xu1

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.

Proceedings of the National Academy of Sciences of the United States of America
|May 21, 2024
PubMed
概括

研究人员开发了一种新的方法,将多糖化合物附着在脂质囊泡上,发现它们意外地使膜变软. 这种技术为控制药物输送载体特性提供了新的途径,并模仿了细胞.

关键词:
胆固醇 胆固醇 胆固醇 是一种巨大的单状脂质囊泡.膜生物物理学的生物物理学微管管吸入方式 微管管吸入方式聚糖是一种多糖化合物.

更多相关视频

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
06:01

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

3.2K
Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

8.4K

相关实验视频

Last Updated: Jun 25, 2025

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
10:43

Preparation, Purification, and Use of Fatty Acid-containing Liposomes

Published on: February 9, 2018

47.3K
Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
06:01

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

3.2K
Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

8.4K

科学领域:

  • 生物物理学的生物物理.
  • 材料科学 材料科学 材料科学
  • 生物化学 生化学

背景情况:

  • 脂质囊泡的特性对于药物输送应用至关重要.
  • 囊泡特征受到脂质组成和聚合物结合的影响.
  • 脂质囊泡的多糖功能化是一个尚未探索的领域.

研究的目的:

  • 开发一种使用多糖化合物使脂质囊泡功能化的一般方法.
  • 为了研究多糖功能化对囊泡膜力学的影响.
  • 为了比较多糖的作用与合成聚合物,如聚乙烯糖醇.

主要方法:

  • 通过结合胆固醇的多糖化合物对巨型单囊 (GUV) 的功能化.
  • 微管吸入技术用于测量膜力学.
  • 在聚糖胺功能化和聚乙烯糖醇功能化GUV之间对机械性能进行比较分析.

主要成果:

  • 多糖功能化意外地使GUVs软化,具有类似液体的膜.
  • 聚乙烯甘醇功能化并没有降低GUVs的拉伸模量.
  • 展示了一种创建膜结合多糖体网状结构的方法.

结论:

  • 多糖功能化提供了一种新的方法来调整脂质囊泡的机械性质.
  • 这种方法可用于创建生物模拟结构,如糖.
  • 这些发现对设计具有定制稳定性和完整性的先进药物输送车辆有影响.