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Updated: May 13, 2026

Dissection and Culture of Mouse Dopaminergic and Striatal Explants in Three-Dimensional Collagen Matrix Assays
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构建人类的3D条纹黑色组合体,以回顾亨廷顿病中中等棘状神经元投射缺陷的情况

Shanshan Wu1,2, Yuan Hong1,2, Chu Chu1,2

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.

Proceedings of the National Academy of Sciences of the United States of America
|May 21, 2024
PubMed
概括

研究人员从人类干细胞开发了3D条纹黑色 (Str-SN) 组合物,以模拟诸如亨廷顿病 (HD) 等神经退行性疾病. 这些模型显示了药物测试和理解电路缺陷的潜力.

关键词:
亨廷顿病是亨廷顿氏病的一种疾病.组合物质组合物质组合物质有机生物有机物条纹-黑道电路.

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Huntington Disease l: Introduction01:21

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...