弥合怀孕期间二手烟暴露与出生体重之间的关系的队列分析中的差异:ECHO计划中的可转移性框架
Andreas M Neophytou1, Jenny Aalborg2, Sheryl Magzamen1
1Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
Environmental health perspectives
|May 21, 2024
概括
怀孕期间接触二手烟 (SHS) 在不同研究中显示出对出生体重的不同影响. 社会人口统计学因素极小地解释了这些差异,表明未测量的因素影响SHS对婴儿健康的影响.
科学领域:
- 环境健康科学 环境健康科学
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 对环境暴露的估计,如对健康结果的二手烟 (SHS),在不同研究中存在很大差异.
- 了解这些变异对于特定的人口健康见解和数据合成至关重要.
研究的目的:
- 评估社会人口统计学因素是否会改变怀孕期间SHS暴露对出生体重的影响.
- 确定这些特征的不同分布如何解释儿童健康结果环境影响 (ECHO) 联盟的队列间观察到的效果变化.
主要方法:
- 在五个ECHO队列 (6,771个二) 中评估SHS暴露对出生体重的影响的效果修改和可传输性.
- 使用梯度增强回归树 (H-统计) 进行效果修改和目标最大概率估计 (TMLE) 进行效果估计.
- 估计了队列之间的传输效应,并将它们与原始估计进行了比较.
主要成果:
- 对SHS暴露对出生体重的观察效应估计在各个队伍之间差异很大,从显著的减少到增加 (包括零).
- 传输效应估计解释了大多数队列对对点估计的最小差异.
结论:
- 发现了对效果修饰和可运输性的微弱到中等证据.
- 未测量的个人和上下文因素,以及潜在的偏见,可能会解释ECHO队伍中观察到的SHS影响估计的变化.
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