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在与男性发生性关系的曾经使用过PrEP的男性中使用PrEP的意愿:一个元分析
Swarnali Goswami1, Taylor Gannon2, Saara Nasruddin3
1Complete HEOR Solutions (CHEORS), Chalfont, PA, USA (At the time this study was conducted, Dr. Goswami was a graduate student in the Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, USA).
AIDS care
|May 21, 2024
概括
一项综合分析发现,58%的美国与男性发生性关系 (MSM) 的艾滋病毒暴露前预防 (PrEP) 素的男性愿意使用PrEP. 定制信息并专注于高艾滋病毒流行率地区可以提高吸收率.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 预防艾滋病毒/艾滋病 预防
背景情况:
- 艾滋病毒仍然是一个重大的公共卫生问题,特别是在美国与男性发生性关系的男性 (MSM) 中.
- 暴露前预防 (PrEP) 是一种高效的生物医学干预措施,用于预防艾滋病毒.
- 了解未曾使用PrEP的MSM中使用PrEP的意愿对于优化HIV预防策略至关重要.
研究的目的:
- 确定美国与男性发生性关系 (MSM) 的 PrEP-naive男性中使用艾滋病毒暴露前预防 (WTUP) 的意愿的综合估计.
- 为了确定可能影响WTUP在这个群体中的因素.
- 为有针对性的艾滋病毒预防工作提供信息.
主要方法:
- 在PubMed,Embase,Web of Science,CINAHL和PsycINFO进行了系统的文献搜索,寻找2005年1月至2022年5月期间发表的研究.
- 纳入标准侧重于以英语为基础的美国前不使用PREP的MSM中关于WTUP的定量数据.
- 使用随机效应模型的元分析被用于计算聚合流行率比例,评估异质性并进行子组分析.
主要成果:
- 十五项研究符合纳入标准.
- 分析显示,WTUP的综合流行比例为0.58 (95%CI为0.54-0.61),表明58%的PREP-naiveMSM愿意使用PREP.
- 观察到高的跨研究异质性,研究样本年龄和地理区域显著调节了聚合的WTUP估计.
结论:
- 在美国,相当一部分从未使用过PrEP的MSM表示愿意使用PrEP.
- 加强PrEP吸收的策略应该考虑适合年龄的信息,并专注于艾滋病毒发病率较高的美国地区.
- 需要进一步的研究和有针对性的干预措施来弥合 PrEP 使用的意愿和实际使用之间的差距.
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