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用PET/CT进行体内活性和吸收剂量的量化方法的比较,这些方法是在90放射栓塞后使用PET/CT进行的

Eric Courtney Henry¹, Armeen Mahvash², Benjamin P Lopez¹

¹Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Medical physics

|May 21, 2024

概括

在放射栓塞后精确的-90 (90Y) PET/CT剂量测量需要考虑成像错误. 扩大感兴趣的体积 (VOI) 确保基于图像的活动估计匹配给出的活动,提高剂量准确性.

科学领域:

核医学是一种核医学.
辐射疗法辐射疗法
医学成像医学成像

背景情况:

-90 (90Y) 定子发射断层扫描 (PET) /计算机断层扫描 (CT) 成像对于90Y放射栓塞 (90Y-RE) 后的voxel剂量测量至关重要.
在体内90Y-PET/CT成像和剂量定量的准确性受到运动模糊,共同注册的不准确性和算法变化的限制.
了解这些局限性对于精确的治疗计划至关重要.

研究的目的:

评估90Y-RE后基于90Y-PET/CT的活性估计的准确性.
为了比较基于90Y-PET/CT的不同voxel剂量计算法的性能.

主要方法:

与TheraSphere一起接受90Y-RE的35名患者进行了90Y-PET/CT成像.
使用剂量校准器测量给药活性 (Aadmin) 和暴露率.
基于图像的活性 (Aimage) 被计算在透体积 (PV) 和扩展轮 (PV+2cm) 中.
剂量计算法包括voxel S值 (VSV),局部沉积方法 (LDM) 和具有已知活性的LDM (LDMKA).

主要成果:

在PV中的Aimage低估了Aadmin,但在使用扩展的PV+2cm轮时,这种偏差得到解决.
在LDM和VSV剂量测算算法中,在感兴趣的卷中显示出高相关性 (R2>0.99),偏差最小 (<3%).
LDMKA与VSV呈现中度相关性 (R2~0.80-0.86),估计剂量大约20%以上.

结论:

在PV中Aimage的总和低估了Aadmin; VOI扩展通过考虑成像限制来纠正这一点.
在临床上,LDM和VSV剂量测量之间的差异是微不足道的.
与VSV相比,LDMKA提供了~20%高的剂量估计.
由于LDMKA的强度,建议在90Y-RE后进行准确的90Y-PET/CT剂量计.

关键词:

聚乙烯/聚乙烯/聚乙烯这是一个SIRT.剂量测量方法剂量测量方法放射性栓塞是一种放射性栓塞.伊-90-90是一种.

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