连续脏替代疗法开始后净超率与尿液输出和液体平衡的相互作用:一个多中心研究
Kyle White1, Kevin B Laupland2, Rinaldo Bellomo3
1Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Journal of critical care
|May 21, 2024
概括
在连续脏置换疗法 (CRRT) 期间,高净超率 (NUF) 并没有显著影响尿液输出 (UO). 在CRRT前的液体平衡也没有与减少的UO相关,这表明NUF不会影响功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临界护理医学 临界护理医学
- 脏替代疗法治疗 脏替代疗法
背景情况:
- 持续置换疗法 (CRRT) 是急性损伤的关键治疗方法.
- 在CRRT期间的高净超过率 (NUF) 可能会影响尿液输出 (UO).
- 在调节这种关系方面,CRRT前流体平衡 (FB) 的作用尚不清楚.
研究的目的:
- 在CRRT启动时调查NUF和UO之间的关联.
- 确定CRRT前的FB是否调节了NUF和UO之间的关系.
主要方法:
- 追溯队列研究包括1030名在两个三级重症监护室接受CRRT的患者.
- 在CRRT启动后的最初24小时内分析NUF,UO和FB数据.
- 多变量分析以潜在的混因素进行调整.
主要成果:
- 在CRRT开始后,观察到每小时平均UO显著下降 (25.5毫升至11.9毫升,P<0.001).
- 在调整混因子 (p = 0.064) 后,较高的NUF与较低的UO没有显著的关联.
- 在CRRT前,FB没有调节NUF和UO之间的关系.
结论:
- 增加的NUF率与CRRT开始后的UI更大的立即或持续减少没有显著联系.
- 在CRRT前的液体平衡没有影响UA的减少.
- 在这种情况下,研究结果不支持NUF对功能有直接影响.
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