由通过NLRP3炎症酶激活的化多化乙硫酸盐 (F-53B) 诱导的胎盘炎症损伤
Chu Chu1, Hao Ran2, Yang Zhou3
1Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Road, Guangzhou 510080, China; Department of Reproductive Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan 2nd Road, Guangzhou 510080, China; Joint International Research Laboratory of Environment and Health, Ministry of Education,Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
化多化乙硫酸盐 (F-53B) 暴露会导致小鼠的胎盘炎症和损伤. 这项研究揭示了F-53B.
科学领域:
- 环境毒理学环境毒理学
- 生殖毒理学 生殖毒理学
- 透和多基基物质 (PFAS) 的使用
背景情况:
- 化多化乙硫酸盐 (F-53B) 与不利的出生结果有关.
- 目前尚不清楚F-53B对胎盘的毒性.
- 调查F-53B对胎盘健康的影响对于生殖风险评估至关重要.
研究的目的:
- 为了研究F-53B对胎盘损伤的影响.
- 阐明F-53B诱导的胎盘损伤背后的分子机制.
- 在小鼠模型中评估F-53B的生殖毒性.
主要方法:
- 怀孕的小鼠通过饮用水暴露在F-53B (0.8或8微克/千克/天) 中,从妊娠日0.5-14.5.5开始.
- 分析了胎盘体重和细胞病理学.
- 评估了亡,NF-κB信号传递,以及与亡相关的分子 (caspase3,IκB-α,caspase1,IL-1β,IL-18,GSDMD).
主要成果:
- 暴露于F-53B,特别是8μg/kg/天,显著增加了胎盘重量,并引起了他的病理变化.
- 观察到胎盘亡 (caspase3激活) 和NF-κB通路激活 (IκB-α酸化) 的增加.
- F-53B提高了炎症性细胞因子和NLRP3炎症组分的调节,导致胎盘组织中的热亡.
结论:
- 暴露于F-53B会在小鼠胎盘中诱导显著的炎症损伤和热.
- 这些发现表明F-53B在环境相关度下具有潜在的生殖毒性.
- 需要进一步的研究来确认人类人口的生殖健康风险.
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