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缓解DSS诱导的大肠炎小鼠的抑郁类行为:探索Poncirus trifoliata提取物中的纳林丁和庞西林

Kang-In Lee¹, Min-Soo Kim², Heung Joo Yuk¹

¹KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|May 21, 2024

概括

花三叶草提取物显示出治疗炎症性肠病 (IBD) 和相关心理健康问题的潜力. 这种天然剂可改善肠道炎症,并表现出类似抗抑郁药的效果,提供双重作用的治疗方法.

科学领域:

胃肠病学和神经病学
自然产品化学自然产品化学

背景情况:

炎症性肠道疾病 (IBD),如性结肠炎和克罗恩病,经常与精神健康障碍同时发生.
双向的肠-大脑轴方法对于管理IBD及其心理并发症至关重要.

研究的目的:

为了研究Poncirus trifoliata提取物 (PT) 对IBD的治疗潜力.
评估PT对肠道炎症和相关的神经炎症和抑郁行为的影响.

主要方法:

用一种硫酸 (DSS) 诱导的大肠炎小鼠模型来评估PT的疗效.
超高性能液体染色学四极飞行时间 (UPLC-qTOF) 确定了关键的生物活性成分.
开放场测试 (OFT) 和尾部悬浮测试 (TST) 评估了类似抗抑郁药的效果.

主要成果:

在DSS诱导的大肠炎中,PT的使用改善了体重减轻和结肠炎症.
PT抑制了活性氧物种 (ROS) 介导的亡,恢复了结肠长度和肠细胞完整性.
PT表现出类似抗抑郁药的效果,并降低了海马中的神经炎症.

结论:

富含庞西林和纳林金的Poncirus trifoliata提取物有效治疗IBD的症状.
PT作为双向治疗剂,改善肠道炎症和与IBD相关的精神障碍.

关键词:

抑郁症抑郁症抑郁症炎症性肠道疾病炎症性肠道疾病纳林丁 (Naringin) 是一个名为"纳林丁"的东西.尸体灭 (Necroptosis) 是一种死亡的过程.这就是Ponzirinirin.这种植物是Poncirus trifoliata.

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