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从玻璃化加热周期的单子子子的子宫内膜厚度和出生体重之间的关联:一个回顾性队列研究

Jiwei Sun¹, Xiaojie Liu², Tong Wu³

¹State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, The Second Hospital, Shandong University, 250012, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China; Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250012, China; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China; School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Reproductive biomedicine online

|May 21, 2024

概括

子宫内膜厚度会影响使用激素替代疗法的冷解胚胎移植周期中的出生体重. 薄的子宫内膜会增加妊娠年龄小的婴儿的风险,而厚度与出生体重较高无关.

科学领域:

生殖内分泌学和不孕不育问题
孕产妇和胎儿医学孕产妇和胎儿医学
辅助生殖技术辅助生殖技术

背景情况:

子宫内膜厚度 (EMT) 是成功的胚胎植入和怀孕结果的关键因素.
在冷解胚胎移植 (FET) 周期中,EMT和婴儿出生体重之间的关系需要进一步澄清,特别是关于不同的准备方案.

研究的目的:

为了研究子宫内膜厚度 (EMT) 和单子婴儿的出生体重之间的关联.
在FET循环中,比较自然循环 (NC) 和激素替代疗法 (HRT) 协议之间的结果.

主要方法:

回顾性队列研究 (2016年1月 - 2019年12月),包括FET周期的单独分娩.
参与者分为NC (n=8132) 和HRT (n=4975) 组.
具有受限制立方线的多变量回归模型分析了EMT对出生体重和妊娠年龄 (SGA/LGA) 小/大状态的影响.

主要成果:

在HRT组中,EMT<8.0毫米与增加SGA风险相关 (aOR1.85).
在HRT组中,在EMT和出生体重之间观察到一个反转的U形关系.
在NC组中,EMT和出生体重z-score或SGA/LGA之间没有发现显著的关联.

结论:

在HRT周期中的薄子宫内膜与较低的出生体重z分数和较高的SGA风险有关.
在自然周期中没有观察到EMT与出生体重或SGA之间的显著关联.
由于潜在的不良分娩结果,经受FET的HRT治疗的薄子宫内膜女性需要专门的注意.

关键词:

出生时的体重是多少子宫内膜厚度子宫内膜厚度在冷解后的胚胎移植过程中.激素替代疗法是一种激素替代疗法.自然循环的自然循环.对于妊娠年龄来说,小的

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