感染SARS-CoV-2,接种疫苗和体外受精治疗:一个前性队列研究
Xudong Zhang1, Xinyao Li1, Wanmeng Chen1
1Centre of Reproductive Medicine, Department of Obstetrics and Gynaecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China; Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodelling of Liaoning Province, Shenyang, Liaoning 110022, PR China.
在体外受精 (IVF) 后90天内感染COVID-19可能会降低胚胎质量,特别是未接种疫苗的个体. 然而,SARS-CoV-2感染在该研究中没有影响怀孕或早产率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 传染性疾病 传染性疾病
- 在体外受精过程中受精.
背景情况:
- COVID-19对女性生殖健康和体外受精 (IVF) 结果的影响仍然存在争议和不清楚.
- 调查SARS-CoV-2感染时间和随后的试管婴儿治疗之间的关系对于了解潜在的生殖后果至关重要.
研究的目的:
- 调查SARS-CoV-2感染后试管婴儿治疗时间和生殖结果之间的关系.
- 评估疫苗接种情况对这些结果的影响.
主要方法:
- 一项前性队列研究,涉及920个SARS-CoV-2感染后的IVF周期.
- 利用修改后的Poisson和后勤回归模型来分析卵细胞,胚胎和临床结果.
- 根据女性参与者的疫苗接种状况进行了分层分析.
主要成果:
- 在试管婴儿后三个月内感染SARS-CoV-2与较少的可用和最高质量的胚胎有关.
- 与完全接种疫苗的妇女相比,未接种疫苗或部分接种疫苗的妇女在90天内感染,卵细胞检索和胚胎质量降低.
- COVID-19感染并没有显著影响生化妊娠,临床妊娠,植入或早期堕胎率.
结论:
- 在SARS-CoV-2感染后90天内开始试管婴儿治疗可能会降低获得活力和高质量的胚胎的可能性,特别是在未接种疫苗的个体中.
- 女性COVID-19感染并没有对怀孕建立或早期怀孕丧失产生负面影响.
- 需要进一步的严格研究来验证这些发现.
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