在未经治疗的晚年抑郁症中主观和客观的认知功能:以共患性泛性焦虑症为中心的探索
Fugui Jiang1, Jing Zhang2, Yang Yi1
1Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China.
Comprehensive psychiatry
|May 21, 2024
概括
与焦虑相关的晚年抑郁症 (LLD) 显著损害了认知功能,尤其是主观能力. 在LLD患者中,焦虑症状严重影响认知缺陷,突出了治疗干预的关键领域.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 晚年抑郁症 (LLD) 是常见的,并与认知能力下降有关.
- 同时存在的泛性焦虑障碍 (GAD) 可能会使LLD的认知障碍恶化.
研究的目的:
- 为了检查同时存在的GAD如何影响未经治疗的LLD患者的认知功能.
- 在LLD中区分焦虑对主观与客观认知表现的影响.
主要方法:
- 招募了77名参与者 (60岁以上):31名LLD,46名LLD和GAD (LLDA),54名健康对照 (HC).
- 确保所有患者在评估前至少两周没有服用药物.
- 进行了全面的神经心理评估,以评估认知领域.
主要成果:
- 与HC相比,LLDA组在记忆,注意力,处理速度,执行功能和主观认知方面表现出显著的认知缺陷.
- 与HC相比,LLD组在记忆,注意力,处理速度和主观认知方面存在缺陷.
- 焦虑症状显著影响LLD患者的主观认知缺陷,对客观表现的影响较小.
结论:
- LLD导致广泛的认知障碍,特别是当GAD存在时,这表明治疗目标.
- 老年抑郁症患者的焦虑症状显著影响主观认知,有助于与痴呆前疾病区分.
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