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Updated: Jun 25, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
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代谢调节器LKB1控制脂肪组织ILC2PD-1表达和线粒体平衡,以防止胰岛素抵抗

Jiping Sun1, Youqin Zhang1, Qingbing Zhang1

  • 1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Immunity
|May 21, 2024
PubMed
概括

脂肪组织2组先天性淋巴细胞 (ILC2s) 中肝激酶B1 (LKB1) 的激活受损导致肥胖症的胰岛素抵抗. 准LKB1-PD-1通路可能治疗代谢性疾病.

关键词:
在PD-1中使用PD-1.第2组是先天性淋巴细胞.胰岛素耐药性是一种胰岛素耐药性.肝激酶 B1 的作用.线粒细胞衰变 (mitophagy) 是一种神经衰变.

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