在白基因组中普遍放松选择
Kyle M Ewart1, Simon Y W Ho1, Al-Aabid Chowdhury1
1School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Proceedings. Biological sciences
|May 21, 2024
概括
与相比,白基因组显示较慢的同义替代率,但较快的非同义替代率和放松的选择,表明独特的基因组适应于eusociality和有效清除有害的遗传突变.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 分子进化分子进化
背景情况:
- 欧社会性是一种复杂的社会结构,几十年来一直吸引着生物学家的兴趣.
- 以前的研究表明,与孤独的昆虫相比,eusocial昆虫的分子进化速率更高.
- 在白中的eusociality的基因组后果仍然不太了解.
研究的目的:
- 为了研究白中eusociality的基因组进化后果.
- 为了比较白基因组与他们的非社会亲属的白基因组.
- 识别与白社会结构和种姓差异化相关的基因组适应.
主要方法:
- 对9个基因组的基因组学分析,包括3个新测序的基因组.
- 对白和之间的同义和非同义替代率进行比较分析.
- 评估选择压力和鉴定与种姓差异化相关的基因.
主要成果:
- 长基因组表现出较低的同义替代率,但比基因组更高的非同义替代率.
- 在24-31%的白基因中发现了普遍放松选择,这可能是由于有效种群规模的减少.
- 在白中没有观察到遗传负载的显著增加,这表明在殖民地层面有效的等位基因清除.
- 确定了基因组适应,包括参与翻译后修改的基因,这可能是种姓差异化的基础.
结论:
- 长的社会性导致了与单独的相比,不同的基因组进化模式.
- 减少有效种群规模和有效的殖民地级别选择塑造了白基因组的演变.
- 特定的基因组适应可能会促进白种的发展和维持.
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