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相关实验视频

Updated: Jun 25, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

柔软但机械坚固的可注射酸水凝,基于酸/酸杂交的加工多功能性.

Xiaoyu Cao¹, Lei Ma¹, Yunfei Tan¹

¹National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China.

International journal of biological macromolecules

|May 21, 2024

概括

研究人员使用一种新的酸-酸混合体开发了可注射的酸水凝. 这项创新克服了分散的挑战,使先进材料应用的均凝成为可能.

关键词:

这是一种CaP-酸盐混合体.可注射的酸盐水凝.有机/无机界面接口

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Last Updated: Jun 25, 2025

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科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
纳米技术纳米技术

背景情况:

酸水凝被广泛使用,但由于界面不相容,从固体来源实现均的诱导凝是具有挑战性的.
现有的方法在软酸盐矩阵内对无机来源的均分散进行斗争.
这限制了对水凝特性和整体性能的控制.

研究的目的:

开发一种新的方法,用于制备可注射的酸水凝与均凝.
为了应对在酸盐溶液中分散无机源的挑战.
创建具有可调节性质和各种应用潜力的酸盐水凝.

主要方法:

在酸盐溶液中合成酸 (CaP),以制造CaP-酸杂交物.
使用物理化学方法描述了纳米级的酸盐-酸复合物.
在酸盐溶液中分散稳定的CaP-酸盐杂交物,形成可注射的水凝.

主要成果:

酸-酸混合物在酸溶液中均分散,即使在离心.
均的凝发生,形成柔软而又坚固的水凝,像透明的纸张和可针织的线程.
可调节的凝时间,可注射性和机械性能是通过调整制备参数来实现的.
这些水凝表现出均的多孔结构,优异的胀,湿和细胞相容性.

结论:

开发的CaP-酸盐混合体是同质酸盐凝形成的有效源.
这种有机/无机杂交策略为创建先进的功能性水凝提供了一个有希望的方法.
可调节性质和优良的特性表明,在各种领域,包括组织工程和药物输送,存在巨大的潜力.