对医学上不可操作的胸部节点转移的废除型立体体辐射疗法 (SBRT) 的前性II期试验
D Franceschini1, M A Teriaca1, P Mancosu1
1Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano - Milan, Italy.
概括
立体性身体放射疗法 (SBRT) 是对胸部结节转移的可行和安全的治疗方法,可实现高局部控制率. 这种方法允许在患有寡聚转移的患者中推迟全身疗法.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 在中节点的寡母转移,由于靠近有风险的器官,因此存在治疗挑战.
- 立体体辐射疗法 (SBRT) 是医疗上不可手术的患者的选择.
- 一项前性观察性II期试验调查了SBRT对胸部节点转移的研究.
研究的目的:
- 评估除性SBRT对胸部节点转移的可行性和安全性.
- 评估局部控制 (LC) 和生存结果.
- 为了确定毒性概况和下一次全身治疗 (TTNS) 的时间.
主要方法:
- 使用了风险适应性SBRT方法,剂量根据转移性节点特征 (50-70 Gy在5-10分数) 变化.
- 允许部分规划目标体积 (PTV) 低剂量.
- 患者的资格要求少于3个节点转移和不可操作性.
主要成果:
- 1年和2年的局部控制分别为93.5%和82.3%.
- 治疗耐受性良好,没有3级或更高的急性或晚期毒性.
- 平均整体存活 (OS) 为59.7个月,1年和2年的OS率分别为96.9%和83.8%.
结论:
- Ablative SBRT对于胸部节点转移是可行的和安全的.
- 风险适应性方法允许推迟开始全身疗法.
- 需要进行更大规模的研究来证实这些发现.
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