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揭示BPA和BPS的复杂性:使用尖端的微生理系统全面了解其毒性作用

Melissa Dibbernn Ganzerla¹, Nathalia de Carvalho Indolfo², Larissa Cleres Moreira Oliveira¹

¹Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil.

Toxicology in vitro : an international journal published in association with BIBRA

|May 21, 2024

概括

对双A (BPA) 和双S (BPS) 的暴露会引起健康风险. 器官芯片技术有效评估了BPA和BPS的毒性,揭示了明显的不良影响和吸收模式.

科学领域:

毒理学毒理学毒理学
生物技术是生物技术.
内分泌学在内分泌学.

背景情况:

双A (BPA) 和其替代品双S (BPS) 引发了健康问题.
尽管BPS作为BPA的替代品,但其研究不足.
器官芯片技术为动物化学毒性测试提供了一种经济有效和道德的替代方案.

研究的目的:

通过多器官在芯片模型评估BPA和BPS的毒理影响.
研究与致癌性,全身毒性和内分泌干扰相关的基因标记物.
通过局部和口服途径比较BPA和BPS的吸收和毒性概况.

主要方法:

使用了3个器官在芯片上的微流体装置,整合了皮肤,肠道和肝脏培养.
通过局部和口服途径管理BPA和BPS.
分析了对毒性和内分泌干扰的基因表达标记物.

主要成果:

BPA显示了预期的吸收,肝损伤和遗传通路调节.
BPS诱导了不良基因表达变化,特别是在局部吸收时,并表现出不同的吸收模式.
器官芯片模型成功地区分了BPA和BPS的毒理影响.

结论:

BPA和BPS都存在毒性风险,需要进一步调查.
器官芯片技术是评估化学安全和开发新药的宝贵工具.
这项研究强调了器官芯片系统在肝脏毒性查方面的实用性,减少了对动物模型的依赖.

关键词:

BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA 在BPS中,BPS是BPS.新的方法方法论方法论在芯片上的器官有毒性有毒性

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