阴茎内丸激素及其前体在亚精子男性中:试点研究
I-Shen Huang1,2,3, Li-Hua Li4,5, Wei-Jen Chen1,3
1Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
The world journal of men's health
|May 21, 2024
概括
患有非阻塞性精子缺血症 (NOA) 的男性比阻塞性精子缺血症 (OA) 有更高的 intratesticular 前体. 在NOA患者中,成功的精子提取与荷尔蒙水平和酶活性的改变有关.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 男人的健康 男人的健康
背景情况:
- 阴精,即射精中缺少精子,会影响男性的生育能力.
- 和它的前体在精子生成中起着至关重要的作用.
- 了解肠道内激素的特征可以提供对男性不孕不育的见解.
研究的目的:
- 分析和前体度在丸间歇液 (TIF) 的男性与精.
- 探索这些激素在丸微环境中的重要性.
- 为了将激素水平与丸精子提取的成功相关联.
主要方法:
- 分析了37个TIF样本,这些样本来自患有阻塞性亚精 (OA) 和非阻塞性亚精 (NOA) 的男性.
- 测量和前体水平使用液体色谱与双重质谱.
- 在OA和NOA组之间对丸精子检索结果的比较分析.
主要成果:
- 患有NOA的男性比患有OA的男性显著更高的 intratesticular丸激素,androstenedione和17-OH孕激素.
- 在接受NOA治疗的患者中,成功的精子采集与降低的androstenedione水平有关.
- 在成功采集精子的男性中观察到 / 安德罗斯坦比率 (HSD17B3活性) 和17-OH孕激素 / 孕激素比率 (CYP17A1活性) 的增加.
结论:
- 在受损与正常精子生成的男性中存在明显的激素生物合成途径.
- 在NOA中激素优化疗法可以导致androstenedione减少和增加HSD17B3活性,改善精子检索成功.
- 这些发现对治疗男性不孕症有潜在的诊断和治疗意义.
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