肠道微生物群在老鼠男性勃起功能障碍中的作用
Zhunan Xu1, Shangren Wang1, Chunxiang Liu2
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
The world journal of men's health
|May 21, 2024
概括
高脂肪饮食会破坏肠道微生物群,导致大鼠发生勃起功能障碍 (ED). 便微生物种移植证实,改变的肠道细菌通过引起炎症和代谢变化导致ED.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢学 代谢学 代谢学
背景情况:
- 勃起功能障碍 (ED) 是一种普遍影响男性性健康的疾病.
- 肠道微生物群显著影响全身健康和疾病.
- 众所周知,高脂肪饮食 (HFD) 可以诱导肠道失调.
研究的目的:
- 调查HFD诱导的肠道微生物群失调对勃起功能的影响.
- 阐明关联肠道失调与ED的潜在机制.
主要方法:
- 雄性Sprague-Dawley大鼠在24周内被食正常饮食 (ND) 或HFD.
- 评估了勃起功能,并通过16SrRNA测序分析了肠道微生物群的组成.
- 建立了便微生物种移植 (FMT) 模型以确认因果关系,随后进行了代谢分析.
主要成果:
- 与ND相比,HFD显著降低了勃起功能和肠道微生物多样性.
- 来自HFD捐赠者的FMT在接受者小鼠中导致勃起功能受损.
- 由HFD诱导的失生症改变了血清代谢物概况,涉及与炎症相关的途径.
结论:
- 由HFD引起的肠道微生物群疾病有助于ED.
- 肠道功能失调会损害肠道屏障,改变新陈代谢,并促进阴茎组织的低级炎症和亡,导致ED.
相关概念视频
Male Sexual Response: Erection & Ejaculation
2.1K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
2.1K
Disorders of the Male Reproductive System
395
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
395


