非心脏性出生缺陷和心血管住院的长期风险
Nathalie Auger1,2,3,4, Gilles Paradis2,3, Jessica Healy-Profitós5,3
1University of Montreal Hospital Centre Research Centre, Montreal, Québec, Canada nathalie.auger@inspq.qc.ca.
Heart (British Cardiac Society)
|May 21, 2024
概括
患有出生缺陷的妇女,包括非心脏缺陷的妇女,面临更高的心血管住院的风险. 这项研究突出了出生异常与产后妇女未来心脏健康之间的联系.
科学领域:
- 生殖健康 生殖健康
- 心血管流行病学心血管流行病学
- 遗传异常是一种先天性异常.
背景情况:
- 已知患有先天性心脏缺陷的患者患心血管疾病的风险较高.
- 非心脏出生缺陷和随后的心血管疾病风险之间的关联仍然不太清楚.
研究的目的:
- 为了研究非心脏出生缺陷和心血管住院的风险之间的关系,在一个大队伍的孕妇.
- 量化与特定类型的非心脏出生缺陷相关的心血管住院风险.
主要方法:
- 进行了一项纵向队列研究,涉及1989年至2022年在加拿大北克省的1,451,409名妇女.
- 患有心脏和非心脏出生缺陷 (尿道,中枢神经系统,消化系统) 的妇女与没有缺陷的妇女进行了比较.
- 考克斯比例危险回归模型被用来评估出生缺陷和心血管住院 (冠状动脉疾病,缺血性中风) 在33年的随访期间之间的关联.
主要成果:
- 与没有任何出生缺陷的妇女相比,患有任何出生缺陷的妇女的心血管住院率更高 (每1000人年7.0),而没有 (每1000人年3.3).
- 非心脏缺陷与心血管住院风险增加1.61倍有关.
- 单独的尿道缺陷 (HR 3.93),中枢神经系统缺陷 (HR 3.33) 和消化系统缺陷 (HR 2.39) 是造成最大风险的. 心脏缺陷的风险最高 (HR 10.30).
结论:
- 无论是心脏还是非心脏的出生缺陷,都与孕期妇女患心血管疾病的风险增加有关.
- 特定的非心脏异常,特别是影响泌尿和中枢神经系统的异常,大大增加了心血管住院的风险.
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