获得乙型肝炎药物的障碍:来自美国和加拿大的定性研究
Michaela Jackson1, Yasmin Ibrahim2, Catherine Freeland2
1Hepatitis B Foundation, Doylestown, Pennsylvania, USA michaela.jackson@hepb.org.
BMJ open
|May 21, 2024
概括
患有乙型肝炎 (PLHB) 的人面临着获得抗病毒药物的重大障碍,包括财务问题,保险障碍和耻辱感. 这些挑战破坏了对乙型肝炎病毒 (HBV) 管理的持续护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 对许多人来说,乙型肝炎病毒 (HBV) 感染需要终身抗病毒治疗.
- 获得必需药物的机会对于管理诸如乙型肝炎等慢性疾病至关重要.
- 了解药物获取障碍对于改善患者结果至关重要.
研究的目的:
- 确定和记录感染乙型肝炎 (PLHB) 的人在获取乙型肝炎病毒 (HBV) 药物时遇到的障碍.
- 探讨影响药物坚持和护理连续性的多方面的挑战.
主要方法:
- 在美国和加拿大的PLHB进行24次在线半结构面试时收集的定性数据.
- 采访的重点是日常生活的影响,感染管理,治疗经验和医疗保健相互作用.
- 参与者包括多样化的人口统计,其中62%的人在研究时接受抗病毒治疗.
主要成果:
- 确定的主要障碍包括财务限制,医疗保险复杂性 (例如,预先授权) 和缺乏可访问,对患者友好的信息.
- 还报告了与乙型肝炎相关的耻辱等无形障碍.
- 这些进入障碍对患者保持一致治疗和护理连续性的能力产生了负面影响.
结论:
- 有关患者,医生和医疗保健系统的重大障碍阻碍了获得HBV抗病毒药物的机会.
- 解决这些多方面的障碍对于改善PLHB的健康结果至关重要.
- 需要进一步的研究,以制定有效的策略,以加强治疗和支持B型肝炎患者的药物获取.
更多相关视频
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.2K
11:00Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
Published on: March 25, 2020
17.1K
相关概念视频
01:21Barriers to Effective Communication II
3.6K
The barriers to effective communication also include cultural barriers, semantic barriers, gender barriers, and time constraints.
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
3.6K
01:14Hepatic Drug Clearance: Role of Transporters
54
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
54
01:23Factors Affecting Drug Distribution: Physiological Barriers
196
Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
196
01:07Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
38
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
A recent model describes pravastatin's hepatobiliary excretion,...
38
01:25Physiological Barriers
3.5K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
3.5K
01:16Hepatic Drug Excretion: Influencing Factors
127
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
127