在肺部早期腺癌的病理诊断中分享经验
Qiulin Liao1, Xiufan Peng2, Yueyuan Liao1
1Department of Pathology, Guangdong Clifford Hospital, Guangzhou, Guangdong, China.
International journal of surgical pathology
|May 21, 2024
概括
对病理学家来说,诊断早期的肺腺癌亚型 (如白皮腺癌) 可能是具有挑战性的. 这项研究基于2021年世卫组织分类提供了新的视角,以提高诊断准确度.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 诊断组织病理学
背景情况:
- 病理学家在区分早期肺腺癌亚型时面临着挑战,包括非典型的腺瘤性增生,adenocarcinoma in situ,微侵袭性腺癌和乳腺腺癌.
- 由于模糊的形态界限,诊断的清晰度和病理学家间的可重现性往往受到限制.
- 准确的诊断和差异诊断需要大量的经验.
研究的目的:
- 根据2021年世卫组织分类,提出区分非典型腺瘤性增生,局部腺癌,微侵袭性腺癌和乳腺腺癌的新观点.
- 为识别早期肺腺癌的侵入性方面提供见解.
- 为早期肺粘膜病变的诊断提供新的视角.
主要方法:
- 在COVID-19大流行期间收集了381个早期肺腺癌样本 (356个单独,25个多焦点).
- 详细的显微镜观察和对434个结节的冷和胺嵌入部分进行比较分析.
- 在诊断早期肺腺癌方面积累的经验的系统总结.
主要成果:
- 根据2021年世界卫生组织分类,提出了区分关键早期肺腺癌亚型的新观点.
- 提供了特定的指导,用于识别早期肺腺癌中的侵入性特征.
- 讨论了对早期肺粘膜病变的诊断的新见解.
结论:
- 虽然有形态学标准存在于非典型的腺瘤性增生,adenocarcinoma in situ,微侵袭性腺癌和乳腺腺癌,精确的边界确定需要经验.
- 早期肺腺癌的手术内冷病理诊断应将成像发现与广泛的形态专业知识相结合.
- 改进的诊断标准和经验对于早期肺腺癌的准确分类至关重要.
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