针对雄激素受体的接种序列与雄激素剥夺疗法影响抗前列腺瘤疗效
Anusha Muralidhar1, Melissa Gamat-Huber2, Sita Vakkalanka2
1Cancer Biology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Journal for immunotherapy of cancer
|May 21, 2024
概括
在雄激素剥夺疗法 (ADT) 之前对前列腺癌小鼠进行疫苗接种,通过增加CD8+T细胞透,提高了生存率. 在ADT后准髓质衍生抑制细胞进一步增强了抗瘤反应.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症治疗 癌症治疗
背景情况:
- 雄激素剥夺疗法 (ADT) 是晚期前列腺癌的主要治疗方法.
- ADT调节免疫微环境,增强T细胞活动和瘤识别.
- 以前的研究表明,ADT与雄激素受体 (AR) DNA疫苗接种相结合,可改善小鼠的生存率.
研究的目的:
- 调查ADT和AR疫苗接种的最佳时间和顺序.
- 评估对瘤免疫微环境和抗瘤疗效的影响.
- 为了提高前列腺癌疫苗的有效性.
主要方法:
- 小鼠前列腺癌模型 (Myc-CaP和TRAMP-C1) 用AR DNA疫苗 (pTVG-AR) 和ADT进行治疗.
- 服用pTVG-AR和ADT的顺序有所变化.
- 分析了瘤生长和透的免疫细胞,包括CD4+,CD8+和Gr1+细胞.
主要成果:
- 在ADT之前的疫苗接种 (pTVG-AR → ADT) 显著改善了抗瘤反应和生存率.
- 这种序列增加了CD4+和CD8+T细胞的透,包括AR特异性的CD8+T细胞.
- 在ADT后,Gr1+髓质衍生抑制细胞 (MDSC) 的增加与T细胞透率降低相关;抑制MDSC改善了结果.
结论:
- 在ADT之前进行AR疫苗接种可以增强抗瘤免疫力,部分是通过增加CD8+T细胞透.
- 针对ADT后的MDSC招募进一步提高了治疗疗效.
- 这些发现为结合ADT,疫苗接种和MDSC抑制治疗前列腺癌的临床试验提供了理由.
相关概念视频
01:30Cancer Vaccines
355
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
355
01:27Tumor Immunotherapy
515
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
515
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K