我们是我们吃的东西:巨细胞和细胞
Kyle T Cunningham1, Rick M Maizels1
1School of Infection and Immunity, University of Glasgow, Glasgow, UK.
Trends in parasitology
|May 21, 2024
概括
死亡细胞的身份改变了巨细胞在细胞分裂过程中. 在Schistosoma mansoni感染中的肝脏巨细胞采用了这些变化,受到Axl/MerTK受体的影响,这有助于控制寄生虫卵负担.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 寄生虫学的寄生虫学
背景情况:
- 巨细胞在组织平衡和病原体清除中发挥着至关重要的作用.
- 吞细胞的过程,即吞细胞的过程,对于解决炎症和预防自身免疫性至关重要.
- 巨细胞的表型可以被它们吞的细胞显著改变.
研究的目的:
- 为了研究死亡细胞的身份如何影响巨细胞在细胞分裂过程中的表型.
- 为了确定肝脏巨细胞在虫感染期间是否表现出类似的表型变化.
- 阐明特定受体在调解这些变化的作用及其对寄生虫负担的影响.
主要方法:
- 使用体外共同培养系统来研究细胞化.
- 使用了Schistosoma mansoni感染的小鼠模型.
- 使用流细胞计和基因表达分析分析了巨细胞表型.
- 通过基因淘汰和药理抑制研究了Axl和MerTK受体的作用.
主要成果:
- 死亡的细胞身份决定了不同的巨细胞两极分化状态后的细胞分裂.
- 感染了Schistosoma mansoni的小鼠的肝脏巨细胞重现了这些因细胞化引起的表型.
- Axl/MerTK受体信号传递对于调解这些巨细胞表型变化至关重要.
- 这些受体介导的变化与肝脏中Schistosoma mansoni卵子负荷的调节直接相关.
结论:
- 巨细胞在化过程中的反应高度依赖于环境,由化的细胞的身份驱动.
- 肝脏巨细胞中的Axl/MerTK介导的细胞分裂是控制Schistosoma mansoni病理的一个关键机制.
- 针对这些途径可以为istosomiasis提供新的治疗策略.
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