含有CaP颗粒和水友性单体的复合材料中的离子释放机制
Rafael Bergamo Trinca1, Beatriz Fonseca Vela1, Handially Dos Santos Vilela1
1University of São Paulo School of Dentistry, Department of Biomaterials and Oral Biology, Av. Prof. Lineu Prestes, 2227, São Paulo, SP 05508-000, Brazil.
概括
在二酸二化物 (DCPD) 复合材料中的水友性聚合物矩阵会增加水的吸附和 (Ca2+) 的释放,特别是在较高的DCPD度下. 机械性能最初没有受到影响,但随着时间的推移而退化.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 聚合物化学 聚合物化学
背景情况:
- 牙科复合材料需要优化的聚合物矩阵来提高性能.
- 了解水吸附,离子释放和机械稳定性对于材料的寿命至关重要.
- 酸二 (DCPD) 是一些牙科修复材料的关键成分.
研究的目的:
- 评估水友性/透性聚合物矩阵对牙科复合材料的影响.
- 评估水吸附/溶解度 (WS/SL), (Ca2+) 释放,机械性能和水解降解.
- 为了研究含有二酸二水合物 (DCPD) 颗粒的复合材料.
主要方法:
- 测试了六种复合配方,其中包括多种DCPD和含水友性单体 (PMGDM/PEGDMA).
- 测量了水吸附/溶解度,Ca2+释放,转化程度,断裂性 (FT) 和双轴屈曲强度/模块 (BFS/FM).
- 使用Salim-Peppas模型分析释放动力学;通过ANOVA/Tukey测试分析的数据.
主要成果:
- 有PMGDM/PEGDMA的复合材料表现出比对照组更高的WS/SL.
- 在40%的DCPD和0.5的PMGDM/PEGDMA中观察到Ca2+释放的增加,放松扩散是主要的释放机制.
- 最初的断裂性没有受到影响,但双轴屈曲强度和模量随着水友网络而下降.
结论:
- 增加矩阵的水友性/透性增强了Ca2+的释放,主要是在高DCPD度下.
- 虽然可以保持初始的机械性能,但长期暴露在水中会导致水友和对照复合材料的降解.
- 水友性聚合物矩阵在含有DCPD的复合材料中提供了离子释放和机械稳定性之间的权衡.
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