临床和血清学的洞察力对神经瘤手臂骨髓变性双
Haidara Kherbek1,2, Christopher Y Itoh1, Catherine Daley1
1Department of Neurology, Mayo Clinic, 200 1St Street, SW, Rochester, MN, 55906, USA.
Journal of neurology
|May 21, 2024
概括
骨骨髓变性双 (BAD) 可能是一个罕见的标志 paraneoplastic自身免疫,不仅仅是神经退行. 在BAD患者中寻找缩和脑干的迹象,以促使对BAD患者进行瘤性评估.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 骨骨髓缩性双 (BAD) 经常与神经退行性疾病,如骨髓缩性侧面硬化症 (ALS) 相关.
- 有限的数据存在于表达为BAD的副发性神经系统综合征.
研究的目的:
- 描述和比较临床和血清学特征 paraneoplastic BAD与神经退行性 BAD.
- 为了识别潜在的诊断标记物和协会对瘤性BAD.
主要方法:
- 对患有BAD类表现的患者的回顾性图表审查.
- 临床和准临床特征的比较,对瘤和神经退行性BAD组之间的比较.
主要成果:
- 确定了四例瘤性BAD病例,这些病例与LUZP4-IgG和KLHL11-IgG抗体以及丸生殖细胞瘤有关.
- 与神经退行性BAD相比,瘤性BAD病例显示出更高的动力衰竭,,听力损失和眼的发生率.
- 炎症性脑脊液 (CSF) 发现存在于瘤病例中,但不在神经退行性病例中.
结论:
- BAD可能是一个罕见的表现 paraneoplastic自身免疫.
- 在BAD中,和脑干功能障碍需要进行瘤评估.
- LUZP4-IgG,KLHL11-IgG和丸生殖细胞瘤与瘤性BAD有关.
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