低收入和中等收入国家的血液储存能力:Covid-19康复性血在背景下
Evan M Bloch1,2,3
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Ebloch2@jhmi.edu.
Current topics in microbiology and immunology
|May 21, 2024
概括
低收入和中等收入国家 (LMICs) 的输血服务面临着重大的安全和可用性挑战. 在LMICs中使用COVID-19康复性血 (CCP) 是有吸引力的,但有可能恶化现有的血液短缺并增加感染传播.
科学领域:
- 公共卫生 公共卫生
- 输血医学 输血医学
- 传染性疾病 传染性疾病
背景情况:
- 低收入和中等收入国家 (LMICs) 的输血能力,包括安全性和充分性,是有限的.
- 挑战包括监管监督,捐赠者选择,收集,测试和监测,导致未满足的临床需求.
- 低于最佳的输血实践和缺乏培训有助于浪费血液.
研究的目的:
- 在现有的血液安全和可用性问题中,将COVID-19康复性血 (CCP) 在LMICs中的使用置于背景.
- 突出与LMIC中CCP使用相关的风险,包括输血传播感染的增加和血液短缺的恶化.
主要方法:
- 审查LMIC中血液输血服务的现有文献和数据.
- 分析血液供献者选择,传染病检测和质量监督方面的挑战.
- 评估COVID-19对血液供应的影响以及CCP的潜在作用.
主要成果:
- 许多LMIC没有达到收集血液的最低门 (10单位/1000人口).
- 依赖非自愿捐献者和不足的检测增加了输血传播感染的风险.
- 由于基础设施不足和可能加剧血液短缺,在LMIC中使用CCP带来了挑战.
结论:
- 在LMIC中使用CCP需要仔细考虑血液供应安全性和可用性的先前存在的限制.
- 在广泛采用CCP等干预措施之前,解决输血服务中的系统性问题至关重要.
- 加强监管监督,供体选择和检测对于减轻风险至关重要.
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