唤醒性差异 脑卒中患者的特征和结果
Emanuele Vincis1, Gabriele Prandin2, Giovanni Furlanis2
1Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Strada Di Fiume, 447 - 34149, Trieste, Italy. emanuelevincis01@gmail.com.
概括
没有接受血栓溶解的女性唤醒中风患者的结果更差. 然而,接受重组组织等离子体激活剂 (rTPA) 治疗的女性表现出更好的神经恢复,突出显示了女性迅速识别WUS的重要性.
科学领域:
- 神经学 神经学
- 脑卒中医学 脑卒中医学
- 血管神经学 血管神经学
背景情况:
- 唤醒性中风 (WUS) 约占缺血性中风的25%.
- 基于性别的WUS患者结局差异仍未得到充分研究,特别是在治疗变异方面.
研究的目的:
- 为了研究基于性别的结果差异,唤醒中风患者.
- 为了比较再生组织等离子体激活剂 (rTPA) 治疗和非rTPA治疗的WUS患者之间的结果,按性别分层.
主要方法:
- 149名WUS患者的临床和成像数据的回顾性分析 (2013年11月 - 2018年12月).
- 患者被分为rTPA治疗 (n=74) 和非rTPA治疗 (n=75) 组.
- 评估的结果包括NIHSS在7天/出院,出院时的mRS,以及 ΔNIHSS.
主要成果:
- 在接受rTPA治疗的患者中,与男性相比,女性从最后一个已知井 (LKW) 到ED入院的时间更长,且 ΔNIHSS 更高.
- 在非rTPA治疗组中,女性比男性更年长,入院前的mRS更高,住院时间更长,在出院时NIHSS更高.
- 总的来说,没有接受rTPA的女性的功能结果更差.
结论:
- 不接受血栓溶解的女性比男性有较差的功能结果.
- 接受rTPA治疗的女性表现出更好的神经恢复 (更大的 ΔNIHSS).
- 在女性中迅速识别WUS至关重要,因为她们似乎从rTPA治疗中获得了更大的益处.
相关概念视频
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